Updating

Is it completely save to update within a playthrough? I ask especially because of the removed esp in v8.40.
I want to have clean as possible savegames regarding script fragments.
For SSE I always use FallrimTools but unfortunately it's not compatible with Oblivion.
OR does not have scripts in the regular scripts folder of the game but that's probably not the only indicator of my concern.
I also ask myself if WryeBash can remove those fragments as well. I've not tested that enough yet.

Oblivion is way less quircky to updating/installing/removing mods  midgame then Skyrim

Updating shouldn't be a problem at all.

Also Oblivion the scripts are inside the ESP/ESM not in an external folder. (And OR itself doesn't have any script)

Good to know. Thanks.

Yep, Oblivion is not like Skyrim as far as updating plugins and it's scripts. You don't have to worry about that with Oblivion.